一、个人简介

张丛，博士，教授，博士生导师。2003年获中国科学院动物研究所博士学位，2003-2005在北京大学122cc太阳集成游戏进行博士后研究，2009-2010年在加拿大蒙特利尔大学访问学者。是多项国家自然科学基金项目、国家重点研发计划课题负责人，是国家优秀青年基金项目评审专家，科技部创新人才推进计划评审专家。是Biology of Reproduction, Clinical Science，Molecular Therapy - Nucleic Acids等多个SCI杂志的审稿人。已在Nature Medicine, Hypertension, Molecular Therapy-Nucleic Acids等杂志上发表或接受第一及通讯作者论文38篇。其中在“Nature Medicine”发表的文章（Nat Med. 2013;19:1061-1066），受到特别关注，该杂志同期为该研究成果配发了相关评论文章(commentary：Nat Med. 2013;19:968-969)并录制了播客（podcast）(网址：http://www. nature.com/multimedia/podcast/ nm/nm-2013-08-06.mp3), Science杂志也在8月将其选为编辑精选（EDITORS’CHOICE：Science 2013;341:823）加以评论。

二、研究方向

1女性生殖与疾病的调控机理研究,通过运用基因敲除及条件性基因敲除小鼠模型、小鼠卵巢移植、病人血浆和胎盘标本分析，重点研究先兆子痫，复发性流产，不孕不育等重大妊娠疾病的发病机制及其调控途径。

2卵泡发育、排卵、黄体化和闭锁过程中的分子调节机理。

我们的研究目标在于阐释人类胚胎着床的关键调控环节，探索先兆子痫，复发性流产，不孕不育等女性生殖疾病的早期诊断和干预的综合措施。

三、承担项目

1.国家重点研发计划“发育编程及代谢调节”重点专项“环境应激和营养失衡所致获得性性状及其代际传递机制”。学术骨干。本人获批90万元（项目负责人单革（中国科技大学），总经费1800万元）。项目编号：2019YFA0802600。起止时间：2019年12月至2024年11月。

2.主持山东大学合作项目：收集反复种植失败患者子宫内膜用于队列研究。2019年9月1日——2020年8月31日。10万元。

3.主持国家自然科学基金面上项目：RNA甲基转移酶NSUN5对先兆子痫发病的影响及机制研究。项目编号：31871512。2019 - 2022, 59万元。

4.国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项“人类胚胎着床调控及相关重大妊娠疾病发生机制”。学术骨干。2017年07月至2020年12月。本人获批79万元（项目负责人王海滨（厦门大学），总经费1428万元）。项目编号：2017YFC1001403。

5.主持国家自然科学基金面上项目：lncRNA HK2P1,PGK1P1/P2作为竞争性RNA抑制蜕膜细胞瓦氏效应诱发先兆子痫的机制。项目编号：31671199。2017-2020, 61万元。

6.主持国家自然科学基金面上项目：蜕膜反应缺陷在人子痫前期发病中的作用及其分子机制。项目编号：31471399。2015 - 2018, 81万元。

7.主持上海交通大学医学院双百人项目：子痫前期的发病机理---蜕膜反应缺陷在其中的作用及机制。项目编号：20152515 2015 - 2017，100万元。

8.主持国家自然科学基金面上项目：肝受体类似物（Liver Receptor Homolog 1, LRH 1)在雌鼠生殖过程中的作用及其机制。项目编号：31172040。2012 - 2015，59万元。

9.主持国家教育部留学基金委科研启动基金项目：肝受体类似物（Liver Receptor Homolog 1, LRH 1)对于小鼠胚胎的调控作用。2013.4-2015.4，3万元。

10.主持山东省自然科学基金：肝受体类似物（Liver Receptor Homolog 1, LRH 1)对于小鼠黄体功能的调控作用。项目编号：ZR2011CM047。2011.7-2014.7，6万元。

11.主持山东省优秀中青年科学家科研奖励基金：Nodal等对小鼠胚胎干细胞的诱导作用。项目编号：2006BS02007。2008-2010，8万元。

四、教学科研成果（论文、专著、专利等）

1.Jing Tong, Zi-Jiang Chen，Cong Zhang. The comparison of the transcriptional profile in the decidua of early-onset and late-onset preeclampsia. 2020.Journal of Obstetrics and Gynaecology Research.2020. July;46 (7): 1055–1066,

2.Wang Naiqiang#, Li Hua#, Zhu Yunqing, Li Na, Chen Zi-Jiang,Zhang Cong*Melatonin protects against Epirubicin-induced ovarian damage.Journal of Reproduction and development. 2020. 66(1)：19-27.

3.Ma Jin#, Yang Jieqiong, Lv Shijian, Gao Minzhi，Sun Yun, Chen Zi-Jiang,Zhang Cong*. Dysfunction of B-cell lymphoma 2/adenovirus E1B 19KD interacting protein 3 in decidua is involved in the pathogenesis of preeclampsia. Journal of Hypertension. 2019. Oct;37(10):2048-2060.

doi: 10.1097/HJH.0000000000002139.

4.Zheng Min#, Zuo Gaoge, Tong Jing, Chen Zi-Jiang, Li Wei-Ping,Zhang Cong*. Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS. Archives of Gynecology and Obstetrics. 2019 (299):1151–1158.

5.Lv Shijian#, Wang Na, Ma Jin, Li Wei-Ping, Chen Zi-Jiang,Zhang Cong*. Impaired decidualization caused by downregulation of Circadian Clock Gene BMAL1 contributes to human recurrent miscarriage.Biology of Reproduction.2019（101）1, July, 138–147.

6.Lv Shijian#, Wang Na, Lv Hong, Yang Jieqiong, Liu Jianwei, Li Wei-Ping*,Zhang Cong*, and Zi-Jiang Chen*. The Attenuation of Trophoblast Invasion Caused by the Downregulation of EZH2 Is Involved in the Pathogenesis of Human Recurrent Miscarriage.Molecular Therapy-Nucleic Acids.2019 Mar 1;14: 377-387. doi: 10.1016/j.omtn.2018.12.011.

7.Shi Feifei#, Li Hua, Wang Enling, Chen Zi-Jiang, andZhang Cong*Melatonin reduces two‐cell block via nonreceptor pathway in mice. Journal of Cellular Biochemistry. 2018 Nov;119(11):9380-9393. DOI: 10.1002/jcb.27255

8.Yang Jieqiong#, Zhang Yachao, Tong Jing, Lv Hong,Zhang Cong*, Chen Zi-Jiang*. Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia.Biology of Reproduction.2018, 98(6), 821-833.

9.Tong Jing#, Yang Jieqiong, Lv Hong, Lv Shijian，Zhang Cong*, Chen Zi-Jiang*. Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1.Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health.2018; 13:37-45.

10.Guo Shujuan#, Yan Xingyu #, Shi Feifei#,Ma Ke, Chen Zi-Jiang andZhang Cong*.Expression and distribution of the zinc finger protein SNAI3 in mouse ovaries and pre-implantation embryos.Journal of Reproduction and Development.2018; 64: 179-186.Doi: 10.1262/jrd.2017-088.

11.Zheng Min#, Tong Jing, Li Wei-Ping*,Chen Zi-Jiang* andZhang Cong*.Melatonin concentration in follicular fluid is correlated with antral follicle count (AFC) and in vitro fertilization (IVF) outcomes in women undergoing assisted reproductive technology (ART) procedures.Gynecological Endocrinology.2018.34(5): 446-450. DOI: 10.1080/09513590.2017.1409713.

12.Lv Hong#, Tong Jing, Yang Jieqiong, Lv Shijian,Li Wei-Ping*,Zhang Cong*, Chen Zi-Jiang*.Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a ceRNA for Hexokinase 2 by Impairing Decidualization.Hypertension.2018. 71: 648-658. DOI:10.1161/HYPERTENSIONAHA.117.10084

13.Zhang Yachao#, Yang Jieqiong#, Lv Shijian, Zhao Dong-Qin, Chen Zi-Jiang*, Li Wei-Ping*,Zhang Cong*.Downregulation of decidual SP1 and P300 is associated with severe preeclampsia.Journal of molecular endocrinology.2018 Feb; 60(2):133-143. Doi: 10.1530/JME-17-0180.

14.Liu Linlin#, Yang Man, Wang Naiqiang,Li Li, Chen Zi-Jiang andZhang Cong*.New insights of subfertility among transplanted women: immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization.Journal of Cellular Biochemistry.2018 Mar;119(3):2964-2977. Doi: 10.1002/jcb.26510.

15.Tong Jing#, Zhao Weixiu, Lv Hong, Li Wei-Ping, Chen Zi-Jiang,Zhang Cong*.Transcriptomic profiling in human decidua of severe preeclampsia detected by RNA sequencing.Journal of Cellular Biochemistry.2018. 119:607-615.

16.Zhang Kaiyue#, Zhong Wanxia, Li Wei-Ping*, Chen Zi-Jiang*andZhang Cong*.miR-15a-5p levels correlate with poor ovarian response in human follicular fluid.Reproduction.2017.Oct; 154(4):483-496.

17.Tong Jing#, Sheng Shile, Sun Yun, Li Huihui, Li Wei-Ping*,Zhang Cong*and Zi-Jiang Chen*.Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve.Reproduction. 2017.Apr; 153(4):443-451.

18.Chang Xin-Lian#, Liu Lisheng, Wang Naiqiang,Chen Zi-Jiang and Zhang Cong*. The function of high-density lipoprotein and low-density lipoprotein in the maintenance of mouse ovarian steroid balance Biology of Reproduction. 2017 Jan 1;97(6):862-872. Article doi: 10.1093/biolre/iox134.

19.Wang Guiping#, Liu Linlin, Guo Shujuan,Zhang Cong*. Expression and distribution of forkhead activin signal transducer 2 (FAST2) during follicle development in mouse ovaries and pre-implantation embryos.Acta Histochemica.2016 Jul;118(6):632-639.doi: 10.1016/j.acthis.2016.07.003.

20.Zhang Dongmei#, Chang Xinlian, Bai Jing, Chen Zi-Jiang, Li Wei-Ping,Zhang Cong*.The Study of Cyclooxygenase 2 in Human Decidua of Preeclampsia.Biology of Reproduction. 2016. Sep; 95(3):1-8.

21.Li Hui-Hui#, Xu Xing-Hua#, Tong Jing, Zhang Kaiyue,Zhang Cong*, Chen Zi-Jiang*.Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and metaanalysis.ReproductiveBiology and Endocrinology.2016.Feb 2; 14(6).doi: 10.1186/s12958-016-0140-6.

22.Wang Guiping#, Zhang Zhaohang#, Chen Cheng#, Zhang Yachao#,Zhang Cong*.Dysfunction of WNT4/WNT5A in deciduas: possible relevance to the pathogenesis of preeclampsia.Journal Hypertension.2016. Apr;34(4):719-727. doi: 10.1097/HJH.0000000000000851

23.Zhang Dongmei#, Cheng Dong#, Liu Tao#, Zhang Yachao, Chen Zi-Jiang,Zhang Cong*.Dysfunction of Liver Receptor Homolog-1 in Decidua: Possible Relevance to the Pathogenesis of Preeclampsia.PLOS ONE.2015. Dec 30;10(12):e0145968.

24.Guo Tao#, Zhang Liang, Cheng Dong, Liu Tao, An Liguo, Li Wei-Ping*,Zhang Cong*.Low-density lipoprotein receptor affects the fertility of female mice.Reproduction Fertility and Development.2015; 27(8): 1222-1232.

25.Guo Cui#, Meng Xiaoqian, Bai Jing, Chen Cheng, Liu Tao, Liu Shuzhen,Zhang Cong*,Li Wei-Ping* Expression and localization of transcription factors SNAIL and SLUG in mouse ovaries and pre-implantation embryos pre-implantation embryos.Cell Tissue Research.2014. 358(2):585–595.

26.Zhang Cong#,Murphy Bruce D.Progesterone is critical for the development of mouse embryos.Endocrine.2014. 46:615-623.

27.Zhang Ting#,Dai Pengyuan#,Cheng Dong, Zhang Liang, Chen Zi-Jiang, Meng Xiaoqian, Zhang Fumiao, Han Xiaoying, Liu Jianwei, Pan Jie, Yang Guiwen,Zhang Cong*.Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility.Reproduction. 2014; 147:141–151.

28.Zhang Cong#, Large Michael J, Duggavathi Raj, DeMayo Francesco J, Lydon John P, Schoonjans Kristina, Kovanci Ertug and Murphy Bruce D.Liver receptor homolog-1 is essential for pregnancy.Nature Medicine.2013;19（8）:1061-1066.

五、荣誉、奖励及参加学术团体的情况：

中国动物学会细胞与分子显微技术学分会常务理事(2018年9月-至今)

中国生理学会生殖科学专业委员会委员(2015年10月-2018年12月)

中国妇幼保健协会妇科内分泌专业委员会青年科研学组委员（2018年4月）

中国动物学会生殖生物学分会委员（2019年9月-2023年9月）

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