何成强
日期: 2021/01/30 作者: 浏览量:
一、个人简介
何成强,男,博士,教授,细胞生物学和生物医药与工程专业研究生导师。承担本科生生物化学、有机化学、病毒学和生物信息学,研究生细胞生物学专业英语和生物信息学教学任务。近年来发表论文60余篇,获省部等各类科研奖励7项,获各级教学奖励4项。指导学生获得全国大学生挑战杯课外科技活动特等奖1项,一等奖1项和三等奖3项,两次获得全国优秀指导教师称号,多次获得山东省优秀指导教师称号。指导多名学生获得山东省省级优秀学位论文,多次获得省级和校级教学成果奖。参与或主持完成各类科研项目6项。被评选为第8届122cc太阳集成游戏杰出青年。
教育经历
1990年9月-1994年7月东北农业大学生物技术专业学习获理学学士学位
1995年9月-1998年7月东北农业大学兽医微生物与免疫学专业学习获农学硕士学位
2001年9月-2004年7月东北农业大学预防兽医学专业学习获农学博士学位
2004年9月-2008年9月122cc太阳集成游戏博士后
工作经历
1998年7月-今122cc太阳集成游戏教师
二、研究领域
动物病毒与宿主的相互作用、RNA病毒快速演化的遗传机制以及通过反向遗传技术研制动物病毒疫苗。
三、教学科研成果(代表性论文、专著、专利等)
1He CQ, He M, He HB, Wang HM, Ding NZ. The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses. Transbound Emerg Dis. 2019 Jun 26. doi: 10.1111/tbed.13282
2He M, He CQ, Ding NZ. Abiotic Stresses: General Defenses of Land Plants and Chances for Engineering Multistress Tolerance. Front Plant Sci. 2018 Dec 7;9:1771. doi: 10.3389/fpls.2018.01771. eCollection 2018. Review.
3Zhao G, Hou P, Huan Y, He C, Wang H, He H. Development of a recombinase polymerase amplification combined with a lateral flow dipstick assay for rapid detection of the Mycoplasma bovis. BMC Vet Res. 2018 Dec 20;14(1):412. doi: 10.1186/s12917-018-1703-x.
4Wang HM, Zhao GM, Hou PL, Yu L, He CQ, He HB. Rapid detection of foot-and-mouth disease virus using reverse transcription recombinase polymerase amplification combined with a lateral flow dipstick. J Virol Methods. 2018 Nov;261:46-50. doi: 10.1016/j.jviromet.2018.07.011.
5Ding NZ, Wang XM, Jiao XW, Li R, Zeng C, Li SN, Guo HS, Wang ZY, Huang Z, He CQ. Cellular prion protein is involved in decidualization of mouse uterus. Biol Reprod. 2018 Aug 1;99(2):319-325. doi: 10.1093/biolre/ioy065.
6Hou P, Zhao G, He C, Wang H, He H. Biopanning of polypeptides binding to bovine ephemeral fever virus G1 protein from phage display peptide library. BMC Vet Res. 2018 Jan 4;14(1):3. doi: 10.1186/s12917-017-1315-x.
7Hou P, Zhao G, Wang H, He C, Huan Y, He H. Development of a recombinase polymerase amplification combined with lateral-flow dipstick assay for detection of bovine ephemeral fever virus. Mol Cell Probes. 2018 Apr;38:31-37. doi: 10.1016/j.mcp.2017.12.003. Epub 2017 Dec 26.
8Zhao G, Wang H, Hou P, He C, He H. Rapid visual detection of Mycobacterium avium subsp. paratuberculosis by recombinase polymerase amplification combined with a lateral flow dipstick. J Vet Sci. 2018 Mar 31;19(2):242-250. doi: 10.4142/jvs.2018.19.2.242.
9Ding NZ, Xu DS, Sun YY, He HB, He CQ. A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination. Sci Rep. 2017 Mar 21;7(1):289.
10He M, Guan SY, He CQ. Evolution of rice stripe virus. Mol Phylogenet Evol. 2017 Apr;109:343-350.
11He CQ,Liu YX, Wang HM, Hou PL, He HB*,Ding NZ*. New genetic mechanism, origin and population dynamic of bovine ephemeral fever virus.Vet Microbiol.2016 ;182:50-6.
12Ji W, Guo Z, Ding NZ, He CQ*. Studying classical swine fever virus: Making the best of a bad virus. Virus Res. 2015;197:35-47.
13Vaccination influences the evolution of classical swine fever virus. Ji W, Niu DD, Si HL, Ding NZ, He CQ. Infect Genet Evol. 2014 Jul;25:69-77.
14Identification of two severe fever with thrombocytopenia syndrome virus strains originating from reassortment. Ding NZ, Luo ZF, Niu DD, Ji W, Kang XH, Cai SS, Xu DS, Wang QW, He CQ. Virus Res. 2013 Dec 26;178(2):543-6.
15Dating the divergence of the infectious hematopoietic necrosis virus. He M, Ding NZ, He CQ, Yan XC, Teng CB. Infect Genet Evol. 2013 Aug;18:145-50.
16Wang H, Liu X, Wu J, Wu G, Yu L, He C*, Yang H, Xie W, Xia X, He H. Bovine fetal epithelium cells expressing shRNA targeting viral VP1 gene resisted against foot-and-mouth disease virus. Virology. 2013;439(2):115-21.
17He CQ*, Meng SL, Yan HY, Ding NZ, He HB, Yan JX, Xu GL. Isolation and identification of a novel rabies virus lineage in china with natural recombinant nucleoprotein gene. PLoS One. 2012;7(12):e49992.
18He CQ, Ding NZ. Discovery of severe Fever with thrombocytopenia syndrome bunyavirus strains originating from intragenic recombination. J Virol. 2012 Nov;86(22):12426-30.
19Wang H, Wu J, Liu X, He H, Ding F, Yang H, Cheng L, Liu W, Zhong J, Dai Y, Li G, He C, Yu L, Li J. Identification of short hairpin RNA targeting foot-and-mouth disease virus with transgenic bovine fetal epithelium cells. PLoS One. 2012;7(8):e42356.
20He CQ, Ding NZ, Mou X, Xie ZX, Si HL, Qiu R, Ni S, Zhao H, Lu Y, Yan HY, Gao YX, Chen LL, Shen XH, Cao RN. Identification of three H1N1 influenza virus groups with natural recombinant genes circulating from 1918 to 2009. Virology. 2012;427(1):60-6.
21Ding NZ, He M, He CQ, Hu JS, Teng JL, Chen J. Yin Yang-1 Regulates the Characterized Murine Focal Adhesion-Associated Protein Promoter. DNA Cell Biol. DNA Cell Biol. 2012 Apr;31(4):496-503.
22He M, He CQ, Ding NZ. Natural recombination between tobacco and tomato mosaic viruses. Virus Res. 2012 Jan;163(1):374-9.
23Yang HT, Jiang Q, Zhou X, Bai MQ, Si HL, Wang XJ, Lu Y, Zhao H, He HB, He CQ*. Identification of a natural human serotype 3 parainfluenza virus. Virol J. 2011 Feb 9;8(1):58.
24Chen F, Wang H, He H, Song L, Wu J, Gao Y, Liu X, He C, Yang H, Chen L, Wang L, Li G, Li Y, Kaplan DE, Zhong J. shRNA-mediated silencing of bovine rotavirus NSP4 gene prevents diarrhoea in suckling mice. J Gen Virol. 2011 Apr;92(Pt 4):945-51.
25He CQ, Ding NZ, He M, Li SN, Wang XM, He HB, Liu XF, Guo HS. Intragenic recombination as a mechanism of genetic diversity in bluetongue virus. J Virol. 2010 Nov;84(21):11487-11495.
26Ding NZ, He M, He CQ, Hu JS, Teng J, Chen J. Expression and regulation of FAAP in the mouse epididymis. Endocrine. 2010 38(2):188-193.
27He CQ*, Xie ZX, Han GZ, Dong JB, Ma LY, Liu JB, Wang D, Tang XF, Liu XP, Pang YS, Li GR. Homologous recombination as an evolutionary force in the avian influenza A virus. Mol Biol Evol. 2009; 26(1):177-187.
28Ding NZ, Wang XM, Sun SW, Song Q, Li SN, He CQ*. Appearance of mosaic enterovirus 71 in the 2008 outbreak of China. Virus Res. 2009;145(1):157-161.
29He CQ*, Ma LY, Wang D, Li GR, Ding NZ. Homologous recombination is apparent in infectious bursal disease virus. Virology. 2009;384(1):51-58.
30Wu ZY, He CQ, Liu YY, Feng Q, Teng JL,Chen JG, A Study of Homologous Recombination in Foot-and-mouth Disease Virus in China. Prog. Biochem Biophys. 2009, 36(6): 689-695.
31Han GZ, He CQ*, Ding NZ, Ma LY. Identification of a natural multi-recombinant of Newcastle disease virus. Virology. 2008; 371(1):54-60.
32He CQ*, Han GZ, Ding NZ, Li GR, Ma LY, Wang D, Liu XP. Evidence of Homologous Recombination in Human and Pig Influenza A Virus. Virology 2008;380(1):12-20.
33Wang D, Fan W, Han GZ, Ma LY, He CQ*. The selection pressure analysis of chicken anemia virus structural protein gene VP1. Virus Gene. 2009 38(2):259-262.
34He CQ, Ding NZ, Fan W. YY1 repressing peroxisome proliferator-activated receptor delta promoter. Mol Cell Biochem. 2008; 308(1-2):247-252.
35He CQ, Ding NZ, Kang J. Germ cell nuclear factor directly represses the transcription of peroxisome proliferator-activated receptors delta. Acta Biochim Biophys Sin. 2008; 40(3): 253-260.
36He CQ*, Ding NZ, Fan W, Wu YH, Li JP, Li YL. Identification of chicken anemia virus putative intergenotype recombinants. Virology. 2007; 366(1):1-7.
37He CQ*, Ding NZ, Chen JG, Li YL. Evidence of natural recombination in classical swine fever virus. Virus Res. 2007; 126(1-2):179-185.
38He CQ Li CC, Wu YH, An LG, Li YL. Cloning and analyzing the promoter of PPARδ. Prog. Biochem Biophys. 2007; 34(4):412-417.
四、获奖
(一)科研成果奖
1.获得国家农业部中华农业科技奖一等奖,2015年,《牛轮状病毒腹泻等传染病防控技术研究与应用》,3/20。
2.获山东省科技进步奖二等奖:2014年,《牛主要病毒病防控技术研究与应用》,3/12。
3.获山东高校优秀科研成果二等奖:2008年,《同源重组导致我省出现新基因型鸡贫血病毒》1/5。
4.获山东高校优秀科研成果一等奖:2009年,《同源重组导致我省出现新基因型鸡贫血病毒》1/5。
5.获山东高校优秀科研成果二等奖:2010年,《RNA病毒遗传多样性分子机制》,1/5
6.获山东高校优秀科研成果三等奖:2013年,《发热伴血小板综合征等RNA病毒的同源重组证据》,2/5。
7.获山东高校优秀科研成果二等奖:2020年,《同源重组是RNA病毒快速进化的重要遗传机制》,1/3。
(二)教学成果奖
1.第十届“挑战杯”全国大学生课外学术科技作品竞赛全国优秀指导教师(指导学生获得第十届“挑战杯”全国大学生课外学术科技作品竞赛一等奖)(2007)
2.第十届“挑战杯”山东省大学生课外学术科技作品竞赛优秀指导教师(指导获得第十届“挑战杯”全国大学生课外学术科技作品竞赛特等奖)(2007)
3.第十一届“挑战杯”全国大学生课外学术科技作品竞赛优秀指导教师(指导学生获得第十一届“挑战杯”全国大学生课外学术科技作品竞赛特等奖)(2009)
4.第十一届“挑战杯”山东省大学生课外学术科技作品竞赛优秀指导教师(指导获得第十一届“挑战杯”全国大学生课外学术科技作品竞赛特等奖)(2009)
5.第十三届挑战杯山东省大学生课外科技作品竞赛特等奖指导教师(山东省优秀指导教师),全国大学生课外科技作品竞赛三等奖指导教师(2013)
6.第十四届挑战杯山东省大学生课外科技作品竞赛特等奖指导教师(山东省优秀指导教师),全国大学生课外科技作品竞赛三等奖指导教师(2015)
7.第十五届挑战杯山东省大学生课外科技作品竞赛一等奖指导教师(2017)
8.2009年、2010年、2011年、2013年、2015年和2018年山东省优秀学位论文(本科)指导教师
9.122cc太阳集成游戏教学成果一等奖,2009年,《师范院校本科生科技创新能力培养》(1/5)
10.122cc太阳集成游戏教学成果奖(二等),2014年,《大学生科研能力培养》(1/5)
11.山东省省级教学成果奖(一等奖),2014年,《培养生命科学专业创新型复合人才,构建全程式多元化实践教学体系》(6/6),
(三)、综合奖励
1.第八届122cc太阳集成游戏杰出青年(2008)
2.122cc太阳集成游戏良师益友(2011)