孙爽

日期: 2020/08/23 作者: 浏览量:



 

简介:

孙爽,女,汉族,理学博士,副教授,硕士生导师,19909月生,山东郓城人。

2022-至今,122cc太阳集成游戏,副教授

2017-2021,122cc太阳集成游戏,讲师

2011-2016,上海交通大学,博士

2007-2011,122cc太阳集成游戏,学士


目前在细胞结构与功能团队从事科研工作,主要研究方向为:

一是病原微生物对宿主细胞骨架特别是微管细胞骨架的影响,关注病原微生物内效应蛋白的类型、分泌特点以及效应蛋白进入宿主细胞后对细胞骨架的组装及功能的影响;二是细胞分裂纺锤体组装的调控。

开设课程:

本科:微生物学、微生物学实验


主持或参加科研项目:

1. ENKD1在纺锤体定向中的作用及分子机制(32000490) 国家自然科学基金青年基金,2021/01-2023/1224万元,主持

2. 假单胞菌的氧化应激反应在其抑菌活性中的作用(ZR2018BC002),山东省自然科学基金博士基金2018/03-2020/129万元,主持

3. OxyR调控根际假单胞菌吩嗪-1-羧酸的合成机理研究2017M622257),第62中国博士后基金面上项目2017/11-2020/125万元,主持

4. HDAC11ε-氨基长链脂肪酰化机制及功能的研究(31970749),国家自然科学基金面上项目,2020.01-2023.12,参与

5. OFIP调节有丝分裂纺锤体定向的机制与功能(31871347) 2019.01-2022.12,参与

6. P49/STRAPMYOCD相互作用协同调控血管平滑肌细胞表型转化的机制 (31871441) 2019.01-2022.12,参与

代表性论文:

1. Sun S*#, Zhou J#,. Phase separation as a therapeutic target in tight junction-associated human diseases. Acta Pharmacol Sin. 2020.

2. Sun S*, Tan LT, Fang YL, Jin ZJ, Zhou L, Goh BH, Lee LH, Zhou J, He YW#. Overexpression of oxyR Increases phenazine-1-carboxylic acid biosynthesis via small rna phrs in the rhizobacterium strain Pseudomonas PA1201. Mol Plant Microbe Interact. 2020;33:488-98.

3. Hu H, Liu M, Sun S#. Pore-forming toxins during bacterial infection: Molecular mechanisms and potential therapeutic targets. Drug Des Devel Ther. 2021; 15:3773-3781

4. Sun S*#, Zhou J. Molecular mechanisms underlying stress response and adaptation. Thorac Cancer. 2018;9:218-27.

5. Sun S*, Chen B, Jin ZJ, Zhou L, Fang YL, Thawai C, Rampioni G, He YW#. Characterization of the multiple molecular mechanisms underlying RsaL control of phenazine-1-carboxylic acid biosynthesis in the rhizosphere bacterium Pseudomonas aeruginosa PA1201. Mol Microbiol. 2017;104:931-47.

6. Sun S*, Zhou L, Jin K, Jiang H, He YW#. Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201. Sci Rep. 2016;6:30352.

7. Jin ZJ, Zhou L, Sun S, Cui Y, Song K, Zhang X, He YW#. Identification of a strong quorum sensing- and thermo-regulated promoter for the biosynthesis of a new metabolite pesticide phenazine-1-carboxamide in Pseudomonas strain PA1201. ACS Synth Biol. 2020;9:1802-12.

8. Zhou L, Sun S, Zhang W, He YW#. Ultra-performance liquid chromatography/mass spectrometry for the detection and quantification of diffusible signal factor (DSF) family quorum-sensing signals. Methods Mol Biol. 2018;1673:97-105.

联系方式:

E-mailshuangsun2017@sdnu.edu.cn

办公地点:122cc太阳集成游戏博物楼,547


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