张丛
日期: 2017/04/23 作者: 浏览量:
张丛
姓名职称:
张丛, 博士,教授,博士生导师。2003年获中国科学院动物研究所博士学位,2003-2005在北京大学122cc太阳集成游戏进行博士后研究,2009-2010年在加拿大蒙特利尔大学访问学者。2015年入选2015年度上交通大学医学院高峰学科—临床医学“临床专职科研队伍”。是多项国家自然科学基金项目、国家重点研发计划课题负责人,是国家优秀青年基金项目评审专家,科技部创新人才推进计划评审专家。是 Biology of Reproduction, Clinical Science,Molecular Therapy - Nucleic Acids等多个SCI杂志的审稿人。已在Nature Medicine, Hypertension, Molecular Therapy-Nucleic Acids,Theriogenology, Biology of Reproduction, Reproduction, Endocrine, Development Growth & differentiation, Stem Cell Development, Journal of Hypertension,Journal of Cellular Biochemistry,Journal of molecular endocrinology, Gynecological Endocrinology, Journal of Reproduction and Development, Reproductive Biology and Endocrinology等杂志上发表或接受第一及通讯作者论文38篇。 其中在“Nature Medicine”发表的文章(Nat Med. 2013;19:1061-1066),受到特别关注,该杂志同期为该研究成果配发了相关评论文章(commentary: Nat Med. 2013;19:968-969) 并录制了播客(podcast )(网址: http://www.nature.com/multimedia/podcast/nm/nm-2013-08-06.mp3), Science 杂志也在8月将其选为编辑精选(EDITORS’ CHOICE:Science 2013;341:823)加以评论。
受教育经历:
1987/09-1991/07, 山东农业大学,畜牧兽医系,农学学士
1991/09-1994/07, 山东农业大学,动物科技学院,农学硕士,导师:王贻节教授
2000/09-2003/06, 中国科学院,动物研究所,理学博士,导师:王琛柱研究员
2003/06-2005/06,北京大学,122cc太阳集成游戏,博士后,导师:邓宏魁教授、丁明孝教授
工作经历:
2012/04-至今, 122cc太阳集成游戏,生命科学院,教授,博士生导师(2015年起)
2009/02-2010/10, 加拿大蒙特利尔大学(University of Montreal), 兽医药学系(Faculty of Veterinary Medicine )动物生殖中心 (CRRA),访问学者
2006/12-2012/04, 122cc太阳集成游戏,生命科学院,副教授
2005/07-2006/12, 122cc太阳集成游戏,生命科学院,讲师
2003/06-2005/06,北京大学,122cc太阳集成游戏,博士后
研究方向:
长期致力于:
1 女性生殖与疾病的调控机理研究, 通过运用基因敲除及条件性基因敲除小鼠模型、小鼠卵巢移植、病人血浆和胎盘标本库分析,重点研究先兆子痫,复发性流产,不孕不育等重大妊娠疾病的发病机制及其调控途径
2卵泡发育、排卵、黄体化和闭锁过程中的分子调节机理。
我们的研究目标在于阐释人类胚胎着床的关键调控环节,探索先兆子痫,复发性流产,不孕不育等女性生殖疾病的早期诊断和干预的综合措施。
开设课程:
本科:发育生物学
硕士研究生:现代分子生物学、动物学专业英语
博士研究生:膜分子生物学
主持或参加科研项目及人才计划项目情况:
1. 国家重点研发计划“发育编程及代谢调节”重点专项“环境应激和营养失衡所致获得性性状及其代际传递机制”。学术骨干。本人获批90万元(项目负责人单革(中国科技大学),总经费1800万元)。项目编号:2019YFA0802600。起止时间:2019 年12月至2024年 11 月。
2. 主持山东大学合作项目:收集反复种植失败患者子宫内膜用于队列研究。2019年9月1日——2020年8月31日。10万元。
3. 主持国家自然科学基金面上项目:RNA甲基转移酶NSUN5对先兆子痫发病的影响及机制研究。项目编号:31871512。2019 - 2022, 59万元。
4. 国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项“人类胚胎着床调控及相关重大妊娠疾病发生机制”。学术骨干。2017年07月至2020年12月。本人获批79万元(项目负责人王海滨(厦门大学),总经费1428万元)。项目编号:2017YFC1001403。
5. 主持国家自然科学基金面上项目:lncRNA HK2P1,PGK1P1/P2作为竞争性RNA抑制蜕膜细胞瓦氏效应诱发先兆子痫的机制。项目编号:31671199。2017-2020, 61万元。
6. 主持国家自然科学基金面上项目:蜕膜反应缺陷在人子痫前期发病中的作用及其分子机制。项目编号:31471399。 2015 - 2018, 81万元。
7. 主持上海交通大学医学院双百人项目:子痫前期的发病机理---蜕膜反应缺陷在其中的作用及机制。项目编号:20152515 2015 - 2017,100万元。
8. 主持国家自然科学基金面上项目:肝受体类似物(Liver Receptor Homolog 1, LRH 1)在雌鼠生殖过程中的作用及其机制。项目编号:31172040。2012 - 2015,59万元。
9. 主持国家教育部留学基金委科研启动基金项目:肝受体类似物(Liver Receptor Homolog 1, LRH 1)对于小鼠胚胎的调控作用。2013.4-2015.4,3万元。
10. 主持山东省自然科学基金:肝受体类似物(Liver Receptor Homolog 1, LRH 1)对于小鼠黄体功能的调控作用。项目编号:ZR2011CM047。2011.7-2014.7,6万元。
11. 主持山东省优秀中青年科学家科研奖励基金:Nodal 等对小鼠胚胎干细胞的诱导作用。项目编号:2006BS02007。2008-2010,8万元。
代表性论文:
1. Jing Tong, Zi-Jiang Chen,Cong Zhang. The comparison of the transcriptional profile in the decidua of early-onset and late-onset preeclampsia. 2020. Journal of Obstetrics and Gynaecology Research. 2020. July; 46 (7): 1055–1066,
2. Wang Naiqiang#, Li Hua#, Zhu Yunqing, Li Na, Chen Zi-Jiang, Zhang Cong* Melatonin protects against Epirubicin-induced ovarian damage. Journal of Reproduction and development. 2020. 66(1):19-27.
3. Ma Jin#, Yang Jieqiong, Lv Shijian, Gao Minzhi,Sun Yun, Chen Zi-Jiang, Zhang Cong*. Dysfunction of B-cell lymphoma 2/adenovirus E1B 19KD interacting protein 3 in decidua is involved in the pathogenesis of preeclampsia. Journal of Hypertension. 2019. Oct;37(10):2048-2060.
doi: 10.1097/HJH.0000000000002139.
4. Zheng Min#, Zuo Gaoge, Tong Jing, Chen Zi-Jiang, Li Wei-Ping, Zhang Cong*. Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS. Archives of Gynecology and Obstetrics. 2019 (299):1151–1158.
5. Lv Shijian#, Wang Na, Ma Jin, Li Wei-Ping, Chen Zi-Jiang, Zhang Cong*. Impaired decidualization caused by downregulation of Circadian Clock Gene BMAL1 contributes to human recurrent miscarriage. Biology of Reproduction.2019 (101)1, July, 138–147.
6. Lv Shijian#, Wang Na, Lv Hong, Yang Jieqiong, Liu Jianwei, Li Wei-Ping*, Zhang Cong*, and Zi-Jiang Chen*. The Attenuation of Trophoblast Invasion Caused by the Downregulation of EZH2 Is Involved in the Pathogenesis of Human Recurrent Miscarriage. Molecular Therapy-Nucleic Acids. 2019 Mar 1;14: 377-387. doi: 10.1016/j.omtn.2018.12.011.
7. Shi Feifei#, Li Hua, Wang Enling, Chen Zi-Jiang, and Zhang Cong* Melatonin reduces two‐cell block via nonreceptor pathway in mice. Journal of Cellular Biochemistry. 2018 Nov;119(11):9380-9393. DOI: 10.1002/jcb.27255
8. Yang Jieqiong#, Zhang Yachao, Tong Jing, Lv Hong, Zhang Cong*, Chen Zi-Jiang*. Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia. Biology of Reproduction. 2018, 98(6), 821-833.
9. Tong Jing#, Yang Jieqiong, Lv Hong, Lv Shijian, Zhang Cong*, Chen Zi-Jiang*. Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2018; 13:37-45.
10. Guo Shujuan#, Yan Xingyu #, Shi Feifei #, Ma Ke, Chen Zi-Jiang and Zhang Cong*. Expression and distribution of the zinc finger protein SNAI3 in mouse ovaries and pre-implantation embryos. Journal of Reproduction and Development. 2018; 64: 179-186. Doi: 10.1262/jrd.2017-088.
11. Zheng Min#, Tong Jing, Li Wei-Ping*, Chen Zi-Jiang* and Zhang Cong*. Melatonin concentration in follicular fluid is correlated with antral follicle count (AFC) and in vitro fertilization (IVF) outcomes in women undergoing assisted reproductive technology (ART) procedures. Gynecological Endocrinology. 2018. 34(5): 446-450. DOI: 10.1080/09513590.2017.1409713.
12. Lv Hong#, Tong Jing, Yang Jieqiong, Lv Shijian, Li Wei-Ping*, Zhang Cong*, Chen Zi-Jiang*. Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a ceRNA for Hexokinase 2 by Impairing Decidualization. Hypertension. 2018. 71: 648-658. DOI: 10.1161/HYPERTENSIONAHA.117.10084
13. Zhang Yachao#, Yang Jieqiong#, Lv Shijian, Zhao Dong-Qin, Chen Zi-Jiang*, Li Wei-Ping*, Zhang Cong*. Downregulation of decidual SP1 and P300 is associated with severe preeclampsia. Journal of molecular endocrinology. 2018 Feb; 60(2):133-143. Doi: 10.1530/JME-17-0180.
14. Liu Linlin#, Yang Man, Wang Naiqiang, Li Li, Chen Zi-Jiang and Zhang Cong*. New insights of subfertility among transplanted women: immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization. Journal of Cellular Biochemistry. 2018 Mar;119(3): 2964-2977. Doi: 10.1002/jcb.26510.
15. Tong Jing#, Zhao Weixiu, Lv Hong, Li Wei-Ping, Chen Zi-Jiang, Zhang Cong*. Transcriptomic profiling in human decidua of severe preeclampsia detected by RNA sequencing. Journal of Cellular Biochemistry. 2018. 119:607-615.
16. Zhang Kaiyue#, Zhong Wanxia, Li Wei-Ping*, Chen Zi-Jiang* and Zhang Cong*. miR-15a-5p levels correlate with poor ovarian response in human follicular fluid. Reproduction. 2017. Oct; 154(4):483-496.
17. Tong Jing#, Sheng Shile, Sun Yun, Li Huihui, Li Wei-Ping*, Zhang Cong* and Zi-Jiang Chen*. Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve. Reproduction. 2017. Apr; 153(4):443-451.
18. Chang Xin-Lian#, Liu Lisheng, Wang Naiqiang, Chen Zi-Jiang and Zhang Cong*. The function of high-density lipoprotein and low-density lipoprotein in the maintenance of mouse ovarian steroid balance Biology of Reproduction. 2017 Jan 1;97(6):862-872. Article doi: 10.1093/biolre/iox134.
19. Wang Guiping#, Liu Linlin, Guo Shujuan, Zhang Cong*. Expression and distribution of forkhead activin signal transducer 2 (FAST2) during follicle development in mouse ovaries and pre-implantation embryos. Acta Histochemica. 2016 Jul;118(6):632-639. doi: 10.1016/j.acthis.2016.07.003.
20. Zhang Dongmei#, Chang Xinlian, Bai Jing, Chen Zi-Jiang, Li Wei-Ping, Zhang Cong*. The Study of Cyclooxygenase 2 in Human Decidua of Preeclampsia. Biology of Reproduction. 2016. Sep; 95(3): 1-8.
21. Li Hui-Hui#, Xu Xing-Hua#, Tong Jing, Zhang Kaiyue, Zhang Cong*, Chen Zi-Jiang*. Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and metaanalysis. Reproductive Biology and Endocrinology. 2016. Feb 2; 14(6). doi: 10.1186/s12958-016-0140-6.
22. Wang Guiping#, Zhang Zhaohang#, Chen Cheng#, Zhang Yachao#, Zhang Cong*. Dysfunction of WNT4/WNT5A in deciduas: possible relevance to the pathogenesis of preeclampsia. Journal Hypertension. 2016. Apr;34(4):719-727. doi: 10.1097/HJH.0000000000000851
23. Zhang Dongmei#, Cheng Dong#, Liu Tao#, Zhang Yachao, Chen Zi-Jiang, Zhang Cong*. Dysfunction of Liver Receptor Homolog-1 in Decidua: Possible Relevance to the Pathogenesis of Preeclampsia. PLOS ONE. 2015. Dec 30;10(12):e0145968.
24. Guo Tao#, Zhang Liang, Cheng Dong, Liu Tao, An Liguo, Li Wei-Ping*, Zhang Cong*. Low-density lipoprotein receptor affects the fertility of female mice. Reproduction Fertility and Development. 2015; 27(8): 1222-1232.
25. Guo Cui#, Meng Xiaoqian, Bai Jing, Chen Cheng, Liu Tao, Liu Shuzhen, Zhang Cong*, Li Wei-Ping* Expression and localization of transcription factors SNAIL and SLUG in mouse ovaries and pre-implantation embryos pre-implantation embryos. Cell Tissue Research. 2014. 358(2):585–595.
26.Zhang Cong#, Murphy Bruce D. Progesterone is critical for the development of mouse embryos. Endocrine. 2014. 46:615-623.
27. Zhang Ting#, Dai Pengyuan#, Cheng Dong, Zhang Liang, Chen Zi-Jiang, Meng Xiaoqian, Zhang Fumiao, Han Xiaoying, Liu Jianwei, Pan Jie, Yang Guiwen, Zhang Cong*. Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. Reproduction. 2014; 147:141–151.
28.Zhang Cong#, Large Michael J, Duggavathi Raj, DeMayo Francesco J, Lydon John P, Schoonjans Kristina, Kovanci Ertug and Murphy Bruce D. Liver receptor homolog-1 is essential for pregnancy. Nature Medicine. 2013;19(8):1061-1066.
荣誉、奖励及参加学术团体的情况:
中国动物学会细胞与分子显微技术学分会常务理事(2018年9月-至今)
中国生理学会生殖科学专业委员会委员(2015年10月-2018年12月)
中国妇幼保健协会妇科内分泌专业委员会青年科研学组委员(2018年4月-至今)
中国动物学会生殖生物学分会委员(2019年9月-2023年9月)